| dc.description.abstract | Purpose: The aim of this study was to evaluate the efficacy
of adrenomedullin on damage associated with cisplatin
ototoxicity created in an experimental animal model.
Materials and Methods: A total of 32 Wistar Albino rats
were separated into 4 groups of 8. To the rats in Group 1
(control), 1% acetic acid was administered intraperitoneally
and intratympanically, to Group 2, cisplatin (10mg/kg/2
days) + intratympanic acetic acid, to Group 3, cisplatin +
intraperitoneal adrenomedullin (12 µg/kg) and to Group
4, cisplatin +0.1- 0.3ml intratympanic adrenomedullin (12
µg/kg). The drugs were administered on the first 5 days
and signal-to-noise ratio (SNR) measurements of the
auditory brainstem response (ABR) and distortion product
otoacoustic emissions (DPOAE) were made on days 0, 5
and 15. The rats were sacrificed and serum and ear tissue
samples were taken for histopathological examination and
examination of oxidative stress levels.
Results: A statistically significant difference was
determined in the cisplatin+intratympanic adrenomedullin
group in the Auditory brain-stem response (ABR)
measurements on days 0, 5 and 15 . In the Distortion
product-evoked otoacoustic emission (DPOAE)
measurements, the between-day differences at 16000
frequency in the cisplatin + intraperitoneal adrenomedullin
group were accepted as statistically significant
Conclusion: Adrenomedullin, which is a strong
vasodilator and antioxidant, was found to have a protective
effect against cisplatin ototoxicity in the cochlea | tr_TR |
